The Ultimate Guide to Choosing Ivermectin Suppliers

Brand Name

US Brand Name

Stromectol

Link to Jiayi Pharmaceutical

Description

Ivermectin is used to treat river blindness (onchocerciasis), intestinal infection from threadworms (strongyloidiasis), and other kinds of worm infections.

Ivermectin is an anthelmintic. It works by interfering with the nerve and muscle functions of worms, by paralyzing and killing them.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

• Tablet

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ivermectin in children weighing less than 15 kilograms (kg). Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ivermectin in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Warfarin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bronchial asthma—Use with caution. May make this condition worse.

Precautions

It is important that your doctor check your or your child's progress at regular visits to make sure that the infection is cleared up completely. Blood tests may be needed to check for unwanted effects.

If you are being treated for river blindness, you may need retreatment and surgery to kill the adult parasite. You will need to see your doctor for follow up care.

If you are being treated for an intestinal infection from threadworms. You will need to have your bowel movements tested to make sure that the infection is gone. It is very important that you have these tests done as often as your doctor orders.

If your symptoms do not improve, or if they become worse, check with your doctor.

This medicine may cause eye, skin, or other serious reactions (eg, Mazzotti reaction), in patients treated for river blindness. Check with your doctor right away if you have eye or eyelid irritation, pain, redness, or swelling, dizziness, lightheadedness, fainting, fast, pounding, or irregular heartbeat or pulse, fever, itching or skin rash, joint or muscle pain, stomach pain, swelling of hands, ankles, feet, or lower legs, swollen, painful, or tender lymph glands in neck, armpit, or groin, unusual tiredness or weakness.

This medicine may cause serious brain and nerve problems. Check with your doctor right away if you have change in consciousness, confusion about identity, place, and time, decreased awareness or responsiveness, loss of consciousness, or severe sleepiness.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

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More common

• Difficulty in moving
• muscle pain or stiffness
• pain in the joints
• swollen, painful, or tender lymph glands in the armpit

Less common

• Black, tarry stools
• bloating or swelling of the face, arms, hands, lower legs, or feet
• chest pain
• chills
• cold sweats
• cough
• dizziness or lightheadedness
• dizziness, faintness, or lightheadedness when getting up from lying or sitting position
• eye or eyelid irritation, pain, redness, or swelling
• fast, pounding, or irregular heartbeat or pulse
• feeling of constant movement of self or surroundings
• fever
• painful or difficult urination
• rapid weight gain
• sensation of spinning
• shakiness in the legs, arms, hands, or feet
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• swollen glands
• tingling of the hands or feet
• trembling or shaking of the hands or feet
• trouble breathing
• unusual bleeding or bruising
• unusual sleepiness
• unusual tiredness or weakness
• unusual weight gain or loss

Rare

• Agitation
• back pain
• bloody eye
• blurred vision
• change in consciousness
• confusion
• decreased awareness or responsiveness
• difficulty in standing or walking
• hallucinations
• headache
• irritability
• loss of bladder control
• loss of bowel control
• loss of consciousness
• mood or mental changes
• redness of the eye
• seizures
• stiff neck
• unusual dullness or feeling of sluggishness
• vomiting

Incidence not known

• Blistering, peeling, or loosening of the skin
• burning, dry, or itching eyes
• change in consciousness
• confusion about identity, place, and time
• dark urine
• diarrhea
• discharge, excessive tearing
• light-colored stools
• loss of consciousness
• red skin lesion often with a purple center
• sensitivity of the eye to light
• swelling of the eyelids
• tearing
• upper right abdominal or stomach pain
• yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Confusion about identity, place, and time
• decreased awareness or responsiveness
• severe sleepiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Constipation
• lack or loss of strength
• loss of appetite
• stomach pain
• swelling or puffiness of the face

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-.

1. Ivermectin (oral route)

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Ivermectin, an anti-parasitic drug often used in animals, has seen a steep rise in prescriptions as patients seek out alternative treatments for COVID-19. If a patient insists on this drug, infectious disease expert John Farley, MD, MPH, has the following advice for doctors: tell that patient to get vaccinated.

“If they're infected and qualify for monoclonal antibodies, they should be treated,” said Dr. Farley, director of the Food and Drug Administration (FDA) Office of Infectious Diseases in the Center for Drug Evaluation and Research.

The FDA has not approved or authorized ivermectin drug for COVID-19, and other federal agencies have warned against its use for preventing and treating the virus. In an episode of “AMA COVID-19 Update,” Dr. Farley discussed the drug’s safety concerns, its potential side effects and the important role of physicians in guiding the unvaccinated to better choices.

The AMA has joined other organizations in opposing the ordering, prescribing or dispensing of ivermectin to prevent or treat COVID-19 outside of a clinical trial.

Little evidence supporting ivermectin

Little evidence supporting ivermectin

Results from small clinical trials touting its benefits has fueled patient interest. However, many of these trials took place in other countries, without any FDA oversight.

“We actually have no way of confirming whether the results reported in those trials are real or not,” Dr. Farley said. Other clinical trials have shown no benefit for ivermectin.

People who choose ivermectin over vaccination could be making a tragic mistake, he cautioned. Physicians should leverage their status as a trusted source to guide patients to another solution.

“If they're sitting in your exam room, even if they're pushing back and giving you a hard time, they trust your recommendations. I would encourage them to get vaccinated for prevention,” said Dr. Farley. Any patient with COVID-19 who is in a high-risk group should get treated with a monoclonal antibody to help stay out of the hospital.

Not always intended for humans

Not always intended for humans

While some ivermectin products are meant for humans, others are specifically formulated for animal or veterinary use. The problem with humans taking drugs intended for animals is those drug formulations often contain ingredients that would be safe for a horse or a cow but not for a human, said Dr. Farley.

The FDA has identified multiple reports of patients who tried to self-medicate with ivermectin products intended for livestock and were subsequently hospitalized.

Some oral formulations have been approved by FDA to treat people with parasitic worms. “It’s a valuable drug, particularly in international settings,” Dr. Farley said. Generally, it’s given as a single-dose treatment and repeated only at recommended intervals.

“We actually don't have data about the safety of taking ivermectin every day for a long period of time,” he added. 

The drug can cause stomach problems, skin rash and itching, and nervous system problems such as dizziness and tremors.

COVID-19 treatment trials underway

COVID-19 treatment trials underway

Everyone wants a pill to treat COVID-19. Clinical trials are underway to examine by-mouth drugs to treat the deadly illness. “That's a very high priority for the government. We need to wait for the results of those trials to know if one of those treatments shows benefit,” said Dr. Farley.

If the trial data is convincing enough, the federal government will work as hard as it can to make that treatment available and provide physicians information they need to maximize benefit and minimize risk, he emphasized.

Patients infected with COVID-19 and at low risk for disease progression who insist on ivermectin should join a clinical trial. This way, they’d get treated with a safe formulation of the drug, at the right dose, said Dr. Farley. Patients can find clinical trials available with contact information at clinicaltrials.gov.

Get the latest news on the COVID-19 pandemic, vaccines and variants, and more reliable information directly from experts and physician leaders with the “AMA COVID-19 Update.”

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